Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms19040998
Keywords
tau; TNAP; muscarinic receptors; synaptopathy; Alzheimer's disease
Funding
- Spanish Ministry of Science and Education [BFU2012-31195]
- European Union project H2020-MSCA-ITN-2017 [766124]
- Universidad Complutense of Madrid (UCM)-Santander Central Hispano Bank [PR41/17-21014]
- UCM
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Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer's disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological hallmarks present in the brains of AD patients. Because NFTs are aberrant intracellular inclusions formed by hyperphosphorylated tau, it was initially proposed that phosphorylated and/or aggregated intracellular tau protein was causative of neuronal death. However, recent studies suggest a toxic role for non-phosphorylated and non-aggregated tau when it is located in the brain extracellular space. In this work, we will discuss
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