Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms19061756
Keywords
immune disorders; microRNA; macrophage; lipid metabolism; chronic inflammation
Funding
- Deutsche Forschungsgemeinschaft [SFB 1123-B4, WE 6160/1-1]
- DZHK (German Centre for Cardiovascular Research) [MHA VD 1.2]
- German Federal Ministry of Education and Research [01KU1213A]
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Macrophages play a crucial role in the innate immune system and contribute to a broad spectrum of pathologies in chronic inflammatory diseases. MicroRNAs (miRNAs) have been demonstrated to play important roles in macrophage functions by regulating macrophage polarization, lipid metabolism and so on. Thus, miRNAs represent promising diagnostic and therapeutic targets in immune disorders. In this review, we will summarize the role of miRNAs in atherosclerosis, metabolic syndrome, and cancer by modulating macrophage phenotypes, which has been supported by in vivo evidence.
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