Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms19030745
Keywords
electrospinning; nanofiber scaffolds; tissue engineering; extracellular matrix-mimicking geometries
Funding
- Arthritis Research UK Fellowship [20631]
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health and Welfare [HI16C0133]
- Korea Institute of Science AMP
- Technology (KIST) project [2Z05190]
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/M000133/1] Funding Source: researchfish
- Versus Arthritis [20631] Funding Source: researchfish
- Korea Health Promotion Institute [HI16C0133020018] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate the formation of artificial functional tissues. In this review, we summarize the fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues. Moreover, several approaches for the formation of three-dimensional fibrous scaffolds arranged in hierarchical structures for tissue engineering are also presented.
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