4.7 Review

Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Repression of telomere-associated genes by microglia activation in neuropsychiatric disease

Golo Kronenberg et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

Microglia-glioma cross-talk: a two way approach to new strategies against glioma

Cataldo Arcuri et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2017)

Article Neurosciences

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Honghua Zheng et al.

JOURNAL OF NEUROSCIENCE (2017)

Review Biochemistry & Molecular Biology

TREM2, Microglia, and Neurodegenerative Diseases

Felix L. Yeh et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Article Cell Biology

High Plasticity of New Granule Cells in the Aging Hippocampus

Mariela F. Trinchero et al.

CELL REPORTS (2017)

Article Cell Biology

The Lifespan and Turnover of Microglia in the Human Brain

Pedro Reu et al.

CELL REPORTS (2017)

Review Immunology

The end of gating? An introduction to automated analysis of high dimensional cytometry data

Florian Mair et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

Review Biochemistry & Molecular Biology

TREM2 Function in Alzheimer's Disease and Neurodegeneration

Jason D. Ulrich et al.

ACS CHEMICAL NEUROSCIENCE (2016)

Article Biochemistry & Molecular Biology

Genetic manipulation of microglia during brain development and disease

Peter Wieghofer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Article Medicine, Research & Experimental

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

Xianyuan Xiang et al.

EMBO MOLECULAR MEDICINE (2016)

Article Neurosciences

A polarizing question: do M1 and M2 microglia exist?

Richard M. Ransohoff

NATURE NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Microglia development follows a stepwise program to regulate brain homeostasis

Orit Matcovitch-Natan et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses

Karpagam Srinivasan et al.

NATURE COMMUNICATIONS (2016)

Article Clinical Neurology

Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease

Kristi Henjum et al.

ALZHEIMERS RESEARCH & THERAPY (2016)

Article Neurosciences

Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1

Sabine Sellner et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Clinical Neurology

TREM2 regulates microglial cell activation in response to demyelination in vivo

Claudia Cantoni et al.

ACTA NEUROPATHOLOGICA (2015)

Article Immunology

Fractalkine in the nervous system: neuroprotective or neurotoxic molecule?

Clotilde Lauro et al.

NEUROIMMUNOMODULATION IN HEALTH AND DISEASE (2015)

Article Biochemistry & Molecular Biology

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model

Yaming Wang et al.

Article Medicine, Research & Experimental

Increased CSF A during the very early phase of cerebral A deposition in mouse models

Luis F. Maia et al.

EMBO MOLECULAR MEDICINE (2015)

Article Medicine, Research & Experimental

TREM2 sustains microglial expansion during aging and response to demyelination

Pietro Luigi Poliani et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Geriatrics & Gerontology

Microglia recapitulate a hematopoietic master regulator network in the aging human frontal cortex

Claudia C. Wehrspaun et al.

NEUROBIOLOGY OF AGING (2015)

Article Geriatrics & Gerontology

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

Henna Martiskainen et al.

NEUROBIOLOGY OF AGING (2015)

Review Neurosciences

NEUROINFLAMMATION IN THE NORMAL AGING HIPPOCAMPUS

R. M. Barrientos et al.

NEUROSCIENCE (2015)

Review Geriatrics & Gerontology

Impact of age-related neuroglial cell responses on hippocampal deterioration

Joseph O. Ojo et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

Review Geriatrics & Gerontology

Microglial cell dysregulation in brain aging and neurodegeneration

Rommy von Bernhardi et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

Article Biochemistry & Molecular Biology

APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

Ileana Soto et al.

PLOS BIOLOGY (2015)

Article Neurosciences

Microglial K+ Channel Expression in Young Adult and Aged Mice

Tom Schilling et al.

Article Clinical Neurology

Microglial and macrophage polarization -new prospects for brain repair

Xiaoming Hu et al.

NATURE REVIEWS NEUROLOGY (2015)

Article Clinical Neurology

Primary age-related tauopathy (PART): a common pathology associated with human aging

John F. Crary et al.

ACTA NEUROPATHOLOGICA (2014)

Article Cell Biology

Homeostatic and injury-induced microglia behavior in the aging brain

Jasmin K. Hefendehl et al.

AGING CELL (2014)

Article Immunology

Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4

Giovanna Pepe et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Cell Biology

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

Gernot Kleinberger et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Pharmacology & Pharmacy

Genomic insights into WNT/13-catenin signaling

Joseph Rosenbluh et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Article Neurosciences

Microglia change from a reactive to an age-like phenotype with the time in culture

Claudia Caldeira et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Clinical Neurology

TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

Janet Cady et al.

JAMA NEUROLOGY (2014)

Article Geriatrics & Gerontology

Normal Cognitive Aging

Caroline N. Harada et al.

CLINICS IN GERIATRIC MEDICINE (2013)

Article Clinical Neurology

Fractalkine/CX3CLI modulates GABAA currents in human temporal lobe epilepsy

Cristina Roseti et al.

EPILEPSIA (2013)

Article Immunology

Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice

Hayley A. Mattison et al.

JOURNAL OF NEUROIMMUNOLOGY (2013)

Article Neurosciences

Evidence for a Gender-Specific Protective Role of Innate Immune Receptors in a Model of Perinatal Brain Injury

Pedro M. Pimentel-Coelho et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Neurosciences

The microglial sensome revealed by direct RNA sequencing

Suzanne E. Hickman et al.

NATURE NEUROSCIENCE (2013)

Article Geriatrics & Gerontology

Insights into TREM2 biology by network analysis of human brain gene expression data

Paola Forabosco et al.

NEUROBIOLOGY OF AGING (2013)

Article Geriatrics & Gerontology

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

Rita Guerreiro et al.

NEUROBIOLOGY OF AGING (2013)

Review Clinical Neurology

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

D. M. Norden et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2013)

Review Clinical Neurology

Review: Activation patterns of microglia and their identification in the human brain

D. Boche et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2013)

Article Medicine, General & Internal

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Thorlakur Jonsson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Geriatrics & Gerontology

Age-associated decrease of SIRT1 expression in rat hippocampus Prevention by late onset caloric restriction

Ana Quintas et al.

EXPERIMENTAL GERONTOLOGY (2012)

Article Neurosciences

Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging

Jana Vukovic et al.

JOURNAL OF NEUROSCIENCE (2012)

Review Clinical Neurology

Progressive multiple sclerosis: pathology and pathogenesis

Hans Lassmann et al.

NATURE REVIEWS NEUROLOGY (2012)

Article Clinical Neurology

Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains

Jun-ichi Satoh et al.

NEUROPATHOLOGY (2012)

Article Anatomy & Morphology

Age-related neuronal loss in the rat brain starts at the end of adolescence

Priscilla Mortera et al.

FRONTIERS IN NEUROANATOMY (2012)

Review Pharmacology & Pharmacy

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Cris S. Constantinescu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance

Tie Fu Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Immunology

CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease

Mibel M. Pabon et al.

JOURNAL OF NEUROINFLAMMATION (2011)

Article Neurosciences

CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents

Raffaela Cipriani et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Geriatrics & Gerontology

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

Adam D. Bachstetter et al.

NEUROBIOLOGY OF AGING (2011)

Article Multidisciplinary Sciences

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa C. Paolicelli et al.

SCIENCE (2011)

Article Immunology

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

Angela M. Wynne et al.

BRAIN BEHAVIOR AND IMMUNITY (2010)

Article Multidisciplinary Sciences

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

Review Immunology

Microglial Physiology: Unique Stimuli, Specialized Responses

Richard M. Ransohoff et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

Review Immunology

TREM and TREM-like receptors in inflammation and disease

Jill W. Ford et al.

CURRENT OPINION IN IMMUNOLOGY (2009)

Review Immunology

The expanding roles of ITAM adapters FcRγ and DAP12 in myeloid cells

Jessica A. Hamerman et al.

IMMUNOLOGICAL REVIEWS (2009)

Article Cell Biology

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

Elsa-Noah N'Diaye et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Differential gene expression in LPS/IFNγ activated microglia and macrophages: in vitro versus in vivo

Christoph D. Schmid et al.

JOURNAL OF NEUROCHEMISTRY (2009)

Review Neurosciences

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

Carol A. Colton

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2009)

Article Neurosciences

Microglia Protect Neurons against Ischemia by Synthesis of Tumor Necrosis Factor

Kate Lykke Lambertsen et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Immunology

Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcR gamma

Ching-Liang Chu et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

Article Biochemistry & Molecular Biology

Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation ROLE OF THE TRANSMEMBRANE DOMAIN

Patricia Hermand et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Endocrinology & Metabolism

Role of CX3CR1 (fractalkine receptor) in brain damage and inflammation induced by focal cerebral ischemia in mouse

Adam Denes et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

Article Multidisciplinary Sciences

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

Ja Wook Koo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State

Laura Helming et al.

SCIENCE SIGNALING (2008)

Review Neurosciences

Neuronal 'On' and 'Off' signals control microglia

Knut Biber et al.

TRENDS IN NEUROSCIENCES (2007)

Review Neurosciences

Opinion -: Chemokines:: a new class of neuromodulator?

William Rostene et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Review Neurosciences

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Uwe-Karsten Hanisch et al.

NATURE NEUROSCIENCE (2007)

Article Medicine, Research & Experimental

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration

Christophe Combadiere et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Immunology

Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis

Laura Piccio et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2007)

Article Neurosciences

Involvement of interferon-γ in microglial-mediated loss of dopaminergic neurons

Matthew P. Mount et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Immunology

Activating and inhibitory functions of DAP12

Isaiah R. Turnbull et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Review Neurosciences

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Michelle L. Block et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Review Cell Biology

Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction

Marcia C. Haigis et al.

GENES & DEVELOPMENT (2006)

Article Immunology

Cutting edge: TREM-2 attenuates macrophage activation

Isaiah R. Turnbull et al.

JOURNAL OF IMMUNOLOGY (2006)

Review Neurosciences

Therapeutic interventions after spinal cord injury

Sandrine Thuret et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Article Neurosciences

Control of microglial neurotoxicity by the fractalkine receptor

Astrid E. Cardona et al.

NATURE NEUROSCIENCE (2006)

Article Multidisciplinary Sciences

Onset and progression in inherited ALS determined by motor neurons and microglia

Severine Boillee et al.

SCIENCE (2006)

Review Neurosciences

Microglial senescence: does the brain's immune system have an expiration date?

Wolfgang J. Streit

TRENDS IN NEUROSCIENCES (2006)

Article Biochemistry & Molecular Biology

SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling

J Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Neurosciences

Regeneration beyond the glial scar

J Silver et al.

NATURE REVIEWS NEUROSCIENCE (2004)

Article Neurosciences

Dystrophic microglia in the aging human brain

WJ Streit et al.

Article Biochemistry & Molecular Biology

Protein kinase A mediates microglial activation induced by plasminogen and gangliosides

KJ Min et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2004)

Article Immunology

Pattern recognition by TREM-2: Binding of anionic ligands

MR Daws et al.

JOURNAL OF IMMUNOLOGY (2003)

Article Neurosciences

Cerebrospinal fluid A beta 40 and A beta 42: Natural course and clinical usefulness

Mikio Shoji et al.

JOURNAL OF ALZHEIMERS DISEASE (2001)

Article Multidisciplinary Sciences

Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival

O Meucci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)