Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms19041209
Keywords
miR-seq; skin color; red tilapia; pigment; comparative analysis
Funding
- Jiangsu Natural Science Foundation for Young Scholars [BK20160203]
- Central Public-Interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences [2017HY-XKQ0203]
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Differentiation and variation in body color has been a growing limitation to the commercial value of red tilapia. Limited microRNA (miRNA) information is available on skin color differentiation and variation in fish so far. In this study, a high-throughput Illumina sequencing of sRNAs was conducted on three color varieties of red tilapia and 81,394,491 raw reads were generated. A total of 158 differentially expressed miRNAs (vertical bar log(2)(fold change)vertical bar >= 1 and q-value <= 0.001) were identified. Target prediction and functional analysis of color-related miRNAs showed that a variety of putative target genes-including slc7a11, mc1r and asip-played potential roles in pigmentation. Moreover; the miRNA-mRNA regulatory network was illustrated to elucidate the pigmentation differentiation, in which miR-138-5p and miR-722 were predicted to play important roles in regulating the pigmentation process. These results advance our understanding of the molecular mechanisms of skin pigmentation differentiation in red tilapia.
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