Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ijms19030682
Keywords
long non-coding RNA; hepatocellular carcinoma; liver cancer; carcinogenesis
Funding
- Swiss National Science Foundation (Ambizione grant) [PZ00P3_168165]
- Oncosuisse [KFS-3995-08-2016, KLS-3639-02-2015]
- Swiss National Science Foundation SNF [310030-159529]
- Swiss National Science Foundation (SNF) [310030_159529] Funding Source: Swiss National Science Foundation (SNF)
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Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being transcriptional noise, increasing evidence indicates that lncRNAs are key players in the regulation of many biological processes, including transcription, post-translational modification and inhibition and chromatin remodeling. Indeed, lncRNAs are widely dysregulated in human cancers, including hepatocellular carcinoma (HCC). Functional studies are beginning to provide insights into the role of oncogenic and tumor suppressive lncRNAs in the regulation of cell proliferation and motility, as well as oncogenic and metastatic potential in HCC. A better understanding of the molecular mechanisms and the complex network of interactions in which lncRNAs are involved could reveal novel diagnostic and prognostic biomarkers. Crucially, it may provide novel therapeutic opportunities to add to the currently limited number of therapeutic options for HCC patients. In this review, we summarize the current status of the field, with a focus on the best characterized dysregulated lncRNAs in HCC.
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