Journal
WORLD JOURNAL OF DIABETES
Volume 5, Issue 6, Pages 924-931Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v5.i6.924
Keywords
Adipokines; Diabetes; Periodontal disease; Periodontal therapy
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The association between adipokines and inflammatory periodontal diseases has been studied over the last two decades. This review was intended to explore the observation that periodontal therapy may lead to an improvement of adipokines in diabetic patients. In summary, substantial evidence suggests that diabetes is associated with increased prevalence, extent and severity of periodontitis. Numerous mechanisms have been elucidated to explain the impact of diabetes on the periodontium. However, current knowledge concerning the role of major adipokines indicates only some of their associations with the pathogenesis of periodontitis in type 2 diabetes. Conversely, treatment of periodontal disease and reduction of oral inflammation may have positive effects on the diabetic condition, although evidence for this remains somewhat equivocal. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
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