Journal
VETERINARY RESEARCH
Volume 45, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13567-014-0127-2
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Funding
- Earmarked Fund for Modern Agro-Industry Technology Research System [nycytx-41-G07]
- Jiangsu Provincial Natural Science Foundation of China [BK20130442]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- National Natural Science Foundation of China [31101827]
- National High-Tech R&D Program of China (863 Program) [2011AA10A200]
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The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (alpha-2,3) and human-type (alpha-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat.
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