Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms19061603
Keywords
mesothelioma; inter-tumor heterogeneity; temporal intra-tumor heterogeneity; spatial intra-tumor heterogeneity; chemoresistance; cancer stem cells; targeted therapy
Funding
- Swiss National Science Foundation [PP00P3_159269]
- Polianthes foundation
- Swiss National Science Foundation (SNF) [PP00P3_159269] Funding Source: Swiss National Science Foundation (SNF)
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Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected patients remains short. The limited efficiency of treatment options is mainly caused by inter- and intra-tumor heterogeneity of mesotheliomas. This diversity can be observed at the morphological and molecular levels. Molecular analyses reveal a high heterogeneity (i) between patients; (ii) within different areas of a given tumor in terms of different clonal compositions; and (iii) during treatment over time. The aim of the present review is to highlight this diversity and its therapeutic implications.
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