Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms19041217
Keywords
microRNA; virus-mediated oncogenesis; viral miRNA; EBV; HHV-8; HBV; HPV; MCPyV; HCV; retroviruses
Funding
- Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Program II (BIOCEV-FAR project) [LQ1604]
- project BIOCEV [CZ.1.05/1.1.00/02.0109]
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To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein-Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), hepatitis C virus (HCV), human herpesvirus 8 (HHV-8) or polyomaviruses, and transregulating retroviruses such as HIV or HTLV-1. Most of these viruses express short noncoding RNAs called miRNAs to regulate their own gene expression or to influence host gene expression and thus contribute to the carcinogenic processes. In this review, we will focus on oncogenic viruses and summarize the role of both types of miRNAs, viral as well as host's, in the oncogenesis.
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