Journal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
Volume 42, Issue 1, Pages 13-20Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2018.3623
Keywords
sirtuin 1; eye disease; deacetylation; resveratrol; degeneration; angiogenesis
Categories
Funding
- National Natural Science Foundation of China [81703134]
- Department of Science and Technology, Hunan [2015TP2007]
- Programs of Science-Technology Commission of Hunan province [2015JC3036]
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Sirtuin (SIRT)1, a member of the SIRT family, is a highly conserved NAD(+)-dependent histone deacetylase, which has a regulatory role in numerous physiological and pathological processes by removing acetyl groups from various proteins. SIRT1 controls the activity of numerous transcription factors and cofactors, which impacts the downstream gene expression, and eventually alleviates oxidative stress and associated damage. Numerous studies have revealed that dysfunction of SIRT1 is linked with ocular diseases, including cataract, age-associated macular degeneration, diabetic retinopathy and glaucoma, while ectopic upregulation of SIRT1 protects against various ocular diseases. In the present review, the significant role of SIRT1 and the potential therapeutic value of modulating SIRT1 expression in ocular development and eye diseases is summarized.
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