Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 15, Issue 8, Pages 816-822Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.25543
Keywords
Gut microbiota; diabetic nephropathy; renin-angiotensin system
Categories
Funding
- National Natural Science Foundation of China [81470957]
- Natural Science Foundation of Jiangsu Province [BK20141343]
- Jiangsu Province Six Talent Peaks Project [2015-WSN-002]
- Project for Jiangsu Provincial Medical Talent [ZDRCA2016077]
- Fundamental Research Funds for the Central Universities [KYCX17-0169, KYZZ15-0061]
- Jiangsu Province Ordinary University Graduate Research Innovation Project [SJZZ16-004]
- Clinical Medical Science Technology Special Project of Jiangsu Province [BL2014080]
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Considerable interest nowadays has focused on gut microbiota owing to their pleiotropic roles in human health and diseases. This intestinal community can arouse a variety of activities in the host and function as a microbial organ by generating bioactive metabolites and participating in a series of metabolism-dependent pathways. Alternations in the composition of gut microbiota, referred to as intestinal dysbiosis, are reportedly associated with several diseases, especially diabetes mellitus and its complications. Here we focus on the relationship between gut microbiota and diabetic nephropathy (DN), as the latter is one of the major causes of chronic kidney diseases. The activation of renin angiotensin system (RAS) is a critical factor to the onset of DN, and emerging data has demonstrated a provoking and mediating role of gut microbiota for this system in the context of metabolic diseases. The purpose of the current review is to highlight some research updates about the underlying interplay between gut microbiota, their metabolites, and the development and progression of DN, along with exploring innovative approaches to targeting this intestinal community as a therapeutic perspective in clinical management of DN patients.
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