Journal
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume 15, Issue 8, Pages 823-831Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijms.25146
Keywords
Saliva collection; healthy volunteers; salivary proteomics; psychological stress; sampling errors; risk management
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Funding
- Cooperative Research Program for Agriculture Science & Technology Development - Rural Development Administration, Republic of Korea [PJ01158104, PJ01389701]
- Bio & Medical Technology Development Program - Ministry of Science, ICT and Future Planning, Republic of Korea [NRF-2017M3A9 E4047243]
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Salivary bioscience technologies such as electrophoresis are widely applied for diagnosing systemic health status. Diagnosis using a saliva sample has emerged as a preferred technique since the sample is easy to collect and the method is inexpensive and non-invasive. Salivary diagnostics have even been identified as potential substitutes for serum protein biomarkers. However, the optimal protocol for collecting saliva has not yet been established. In many scientific settings, such as randomized controlled trials, sampling and statistical errors often occur when handling samples from healthy volunteers. These errors can be due to the psychological behavior of the volunteers, subject nonadherence, questionnaire characteristics, collection methods, and/or sample processing. The purpose of the review presented here is to outline the strategies for managing the risk factors and to minimize the sampling errors during saliva collection in healthy volunteers.
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