Journal
GENES & DEVELOPMENT
Volume 29, Issue 13, Pages 1343-1355Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.262766.115
Keywords
N-6-methyladenosine; m(6)A methyltransferase; RNA demethylase; METTL3-METTL14; mRNA methylation; post-transcriptional regulation
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Funding
- National Institutes of Health [GM071440]
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N-6-methyladenosine (m(6)A) is the most prevalent and internal modification that occurs in the messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a mystery for decades. This modification is installed by the m(6)A methylation writers and can be reversed by demethylases that serve as erasers. In this review, we mainly summarize recent progress in the study of the m(6)A mRNA methylation machineries across eukaryotes and discuss their newly uncovered biological functions. The broad roles of m(6)A in regulating cell fates and embryonic development highlight the existence of another layer of epigenetic regulation at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.
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