Journal
GENES & DEVELOPMENT
Volume 29, Issue 4, Pages 337-349Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.256495.114
Keywords
nuclear genome; nuclear envelope; nuclear pore complex; nucleoporin; transcription control; mitosis; DNA damage
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Funding
- EMBO fellowship
- Human Frontier Science Program fellowship
- National Institutes of Health [R01GM098749]
- Glenn Aging Foundation
- American Cancer Society Award [P30CA014195]
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Nuclear pore complexes (NPCs) are composed of several copies of similar to 30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.
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