Journal
GENES & DEVELOPMENT
Volume 29, Issue 17, Pages 1777-1788Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.266593.115
Keywords
FANCM; Mph1; Fml1; MHF; BLM; replication fork regression; crossover control
Categories
Funding
- National Institutes of Health [GM057814, ES007061, ES015632, CA92584, GM080670]
- American Cancer Society [RSG-12-013-01-CCG]
- Leukemia and Lymphoma Society Scholar Award
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Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATR-mediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes.
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