Journal
GENES & DEVELOPMENT
Volume 29, Issue 13, Pages 1393-1402Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.262170.115
Keywords
chromosome translocations; histone modifications; chromatin structure
Categories
Funding
- Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research
- Howard Hughes Medical Institute-National Institutes of Health fellowship
Ask authors/readers for more resources
Chromosome translocations are well-established hallmarks of cancer cells and often occur at nonrandom sites in the genome. The molecular features that define recurrent chromosome breakpoints are largely unknown. Using a combination of bioinformatics, biochemical analysis, and cell-based assays, we indentify here specific histone modifications as facilitators of chromosome breakage and translocations. We show enrichment of several histone modifications over clinically relevant translocation-prone genome regions. Experimental modulation of histone marks sensitizes genome regions to breakage by endonuclease challenge or irradiation and promotes formation of chromosome translocations of endogenous gene loci. Our results demonstrate that histone modifications predispose genome regions to chromosome breakage and translocations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available