4.1 Article

Development of O/W emulsions containing Euterpe oleracea extract and evaluation of photoprotective efficacy

Journal

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 50, Issue 3, Pages 639-652

Publisher

UNIV SAO PAULO, CONJUNTO QUIMICAS
DOI: 10.1590/S1984-82502014000300024

Keywords

O/W emulsion/development; Euterpe oleracea/pharmacognosy; Euterpe oleracea/glycolic extract/photoprotective efficacy; Sunscreens/development; Sun Protection Factor

Funding

  1. Federal University of Rio Grande do Norte (UFRN)
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  3. UFRN/REUNI

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Euterpe oleracea Mart. is a palm tree popularly known as acai, which is primarily found in northern Brazil. The acai's fruits contain anthocyanins, a class of polyphenols to which antioxidant properties have been attributed. The aim of this work was to develop O/W sunscreens emulsions containing acai glycolic extract (AGE) and to evaluate both their physical stability and photoprotective efficacy. Emulsions containing AGE and sunscreens were formulated using different types and concentrations of polymeric surfactant (acrylates/C 10-30 alkyl acrylate crosspolymer and sodium polyacrylate). The influence of two rheology modifiers (polyacrylamide (and) C13-14/isoparaffin (and) Laureth-7 and Carbomer) on the stability was also investigated. Physical stability was evaluated by preliminary and accelerated studies. Emulsions with 1.0% sodium polyacrylate were stable and exhibited non-newtonian pseudoplastic behavior and thixotropy. Photoprotective efficacy was evaluated by in vivo Sun Protection Factor (SPF) and determination of Protection Factor of UVA (PF-UVA). When AGE was added to the sunscreen emulsion, no significant increase in the in vivo SPF value was observed. The emulsion containing AGE showed PF-UVA = 14.97, 1.69 of the SPF/PF-UVA ratio and a critical wavelength value of 378 nm, and may therefore be considered a sunscreen with UVA and UVB protection.

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