Journal
PEDIATRIC OBESITY
Volume 9, Issue 6, Pages e141-e144Publisher
WILEY
DOI: 10.1111/ijpo.253
Keywords
Infant fat mass; infant weight gain; perinatal programming
Categories
Funding
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [M01 RR00080, UL1 RR024989]
- NIH [HD-11089]
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BackgroundRapid weight gain in infancy has been established as a risk factor for the development of later obesity. ObjectiveWe aimed to investigate the role of changes in infant body composition (assessed via total body electrical conductivity) on the development of overweight/obesity in mid-childhood. MethodsFifty-three term infants were evaluated at birth, three times during infancy and in mid-childhood. Logistic regression was used to determine associations between rates of total weight gain, fat mass gain and lean mass gain during infancy and later overweight/obesity (defined as body mass index [BMI] 85th percentile), adjusted for birth weight and parent education. ResultsAt follow-up (age 9.01.8 years), 30% were overweight/obese. More rapid total weight gain from 0 to 4 months was associated with twofold odds (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.05-3.74, P=0.04) of overweight/obesity in mid-childhood. From 0 to 8 months, more rapid weight gain was associated with nearly fivefold odds (OR 4.76, 95% CI 1.05-21.5, P=0.04), and more rapid fat mass gain was associated with eightfold odds (OR 8.03, 95% CI 1.11-58.2, P=0.04) of later overweight/obesity. ConclusionThis exploratory study suggests that rapid weight gain, especially fat mass gain, in earlier infancy predisposes to mid-childhood overweight/obesity.
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