Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 223, Issue -, Pages 87-107Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2015.09.025
Keywords
Amh; AmhrII; Fish; Brain-pituitary-gonadal axis (BPG-axis); Fsh; Spermatogenesis
Categories
Funding
- United States - Israel Binational Agricultural Research and Development Fund (BARD)
- Deutsche Forschungsgemeinschaft - Germany [Gu208/12-3]
Ask authors/readers for more resources
This review summarizes the important role of Anti-Mullerian hormone (Amh) during gonad development in fishes. This Tgf beta-domain bearing hormone was named after one of its known functions, the induction of the regression of Mullerian ducts in male mammalian embryos. Later in development it is involved in male and female gonad differentiation and extragonadal expression has been reported in mammals as well. Teleosts lack Mullerian ducts, but they have amh orthologous genes. amh expression is reported from 21 fish species and possible regulatory interactions with further factors like sex steroids and gonadotropic hormones are discussed. The gonadotropin Fsh inhibits amh expression in all fish species studied. Sex steroids show no consistent influence on amh expression. Amh is produced in male Sertoli cells and female granulosa cells and inhibits germ cell proliferation and differentiation as well as steroidogenesis in both sexes. Therefore, Amh might be a central player in gonad development and a target of gonadotropic Fsh. Furthermore, there is evidence that an Amh-type II receptor is involved in germ cell regulation. Amh and its corresponding type II receptor are also present in brain and pituitary, at least in some teleosts, indicating additional roles of Amh effects in the brain-pituitary-gonadal axis. Unraveling Amh signaling is important in stem cell research and for reproduction as well as for aquaculture and in environmental science. (C) 2015 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available