Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 221, Issue -, Pages 255-266Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2014.11.021
Keywords
Insulin; Insulin-like peptides; Drosophila melanogaster
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Funding
- Swedish Research Council [VR-2010-5742]
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Taking advantage of Drosophila as a genetically tractable experimental animal much progress has been made in our understanding of how the insulin/IGF signaling (IS) pathway regulates development, growth, metabolism, stress responses and lifespan. The role of IIS in regulation of neuronal activity and behavior has also become apparent from experiments in Drosophila. This review briefly summarizes these functional roles of IIS, and also how the insulin producing cells (IPCs) are regulated in the fly. Furthermore, we discuss functional aspects of the spatio-temporal production of eight different insulin-like peptides (DILP1-8) that are thought to act on one known receptor (dInR) in Drosophila. (C) 2015 Elsevier Inc. All rights reserved.
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