Journal
GENERAL AND COMPARATIVE ENDOCRINOLOGY
Volume 214, Issue -, Pages 62-67Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygcen.2015.01.029
Keywords
Direct development; Thyroid axis; Median eminence; Thyroid-stimulating hormone; Metamorphosis
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Funding
- U.S. National Science Foundation [IBN93-21572, DCB90-I9624, IBN94-19407]
- Undergraduate Research and Creative Activities program at SIUE
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Direct-developing frogs lack, wholly or in part, a wide range of larval features found in metamorphosing species and form adult-specific features precociously, during embryogenesis. Most information on thyroid regulation of direct development relies on hormone manipulations; the ontogeny of many thyroid axis components has not been fully described. This analysis examines differentiation of the median eminence of the hypothalamus and production of thyroid-stimulating hormone (TSH) by the pituitary of the direct-developing frog Eleutherodactylus coqui. The median eminence is established two-thirds of the way through embryogenesis. Cells immunoreactive to human TSH beta antibodies are first detected during embryogenesis and quantitative changes in TSH beta-IR cells resemble those in metamorphosing amphibians. Formation of the median eminence of the hypothalamus and TSH beta production by the pituitary precede or coincide with morphological changes during embryogenesis that occur during metamorphosis in biphasic anurans. Thus, while the onset of neuroendocrine regulation has changed during the evolution of direct development, it is likely that these thyroid axis components still mediate the formation of adult features. (C) 2015 Elsevier Inc. All rights reserved.
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