Journal
GENE EXPRESSION PATTERNS
Volume 17, Issue 1, Pages 1-10Publisher
ELSEVIER
DOI: 10.1016/j.gep.2014.11.002
Keywords
Cartilage development; Wnt signaling; Beta-catenin; Indian hedgehog; PTHrP
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Funding
- American Quarter Horse Foundation
- Oregon State University
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Wnt/beta-catenin, Indian hedgehog (Ihh)/Parathyroid-related peptide (PTHrP) and retinoid signaling pathways regulate cartilage differentiation, growth, and function during development and play a key role in endochondral ossification. The objective of this study was to elucidate the gene and protein expression of signaling molecules of these regulatory pathways in chondrocytes surrounding cartilage canals and the osteochondral junction during neonatal and pre-adolescent development. This study revealed cell-specific and age-related differences in gene and protein expression of signaling molecules of these regulatory pathways. A trend for higher gene expression of PTHrP along the cartilage canals and Ihh along the osteochondral junction suggests the presence of paracrine feedback in articular epiphyseal cartilage. Differential expression of canonical (beta-catenin, Wnt-4, Lrp4, Lrp6) and noncanonical Wnt signaling (Wnt-5b, Wnt-11) and their inhibitors (Dkk1, Axin1, sFRP3, sFRP5, Wif-1) surrounding the cartilage canals and osteochondral junction provides evidence of the complex interactions occurring during endochondral ossification. (C) 2014 Elsevier B.V. All rights reserved.
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