Journal
GENE
Volume 566, Issue 1, Pages 1-7Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2015.04.077
Keywords
MLP; Sarcomere; Muscle structure; Differentiation; Heart failure; Cardiomyopathies; Skeletal myopathies
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Funding
- National Institutes of Health [GM083924, GM114833]
- Elsevier, the publisher of GENE
- European Community [HEALTH-F2-2009-241526]
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Muscle LIM Protein (MLP) has emerged as a key regulator of striated muscle physiology and pathophysiology. Mutations in cysteine and glycine-rich protein 3 (CSRP3), the gene encoding MLP, are causative of human cardiomyopathies, whereas altered expression patterns are observed in human failing heart and skeletal myopathies. In vitro and in vivo evidences reveal a complex and diverse functional role of MLP in striated muscle, which is determined by its multiple interacting partners and subcellular distribution. Experimental evidence suggests that MLP is implicated in both myogenic differentiation and myocyte cytoarchitecture, although the full spectrum of its intracellular roles still unfolds. (C) 2015 Elsevier B.V. All rights reserved.
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