Journal
GENE
Volume 571, Issue 1, Pages 1-8Publisher
ELSEVIER
DOI: 10.1016/j.gene.2015.07.071
Keywords
EPHX1; Gene; Structure; Function; Genotype; Disease
Categories
Funding
- National Institutes of Health [GM089820]
- Elsevier of GENE
- Czech Science Foundation [P303/12/G163]
- European Regional Development Fund [CZ.1.05/2.1.00/03.0076]
Ask authors/readers for more resources
Microsomal epoxide hydrolase (EPHX1) is an evolutionarily highly conserved biotransformation enzyme for converting epoxides to diols. Notably, the enzyme is able to either detoxify or bioactivate a wide range of substrates. Mutations and polymorphic variants in the EPHX1 gene have been associated with susceptibility to several human diseases including cancer. This review summarizes the key knowledge concerning EPHX1 gene and protein structure, expression pattern and regulation, and substrate specificity. The relevance of EPHX1 for human pathology is especially discussed. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available