Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 142, Issue 10, Pages 2068-2079Publisher
WILEY
DOI: 10.1002/ijc.31232
Keywords
double cortin-like kinase 1; colorectal cancer; epithelial-mesenchymal transition; NF-kappa B; PI3K/Akt pathway
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Funding
- National Natural Science Foundation of China [81602512, 91629302, 81572790, 31270818, 91029714]
- China Postdoctoral Science Foundation [2015M581307]
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Double cortin-like kinase 1 (DCLK1) plays important roles during the epithelial-mesenchymal transition (EMT) process in human colorectal cancer (CRC). However, the role of DCLK1 in regulating the EMT of CRC is still poorly understood. In this study, we report evidence that DCLK1 acts as a potent oncogene to drive its extremely malignant character of EMT in an NF-kappa B-dependent manner in CRC cells. Mechanistic investigations showed that DCLK1 induced the NF-kappa Bp65 subunit expression through the PI3K/Akt/Sp1 axis and activated NF-kappa Bp65 through the PI3K/Akt/I kappa B alpha pathway during the EMT of CRC cells. Moreover, we found that silencing the expression of DCLK1 inhibited the invasion and metastasis of CRC cells in vivo. Collectively, our findings identify DCLK1 as a pivotal regulator of an EMT axis in CRC, thus implicating DCLK1 as a potential therapeutic target for CRC metastasis.
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