Journal
GENE
Volume 556, Issue 2, Pages 192-198Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2014.11.053
Keywords
Breast cancer; MicroRNA; Cancer subtype; Survival analysis
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MicroRNAs (miRNAs) are a kind of short non-coding RNAs, of about 22 nucleotides in length, which modulate and sometimes degrade the target mRNAs thereby regulating a number of cellular functions. Recent research in this area establishes the involvement of miRNAs in various disease progressions, including certain types of cancer development Further, genome-wide expression profiling of miRNAs has been proven to be useful for differentiating various cancer types. In this paper, we have used miRNA expression profiles over a large set of breast cancer tumor samples for identifying subtypes of breast cancers. The experimental results demonstrate that miRNAs carry a unique signature that distinguishes cancer subtypes and reveal new cancer subtypes. Additional survival analyses based on clinical data also strengthen this claim. (C) 2014 Elsevier B.V. All rights reserved.
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