Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 110, Issue -, Pages 17-29Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.11.113
Keywords
Injectable hydrogel; Drug delivery; Carbohydrate polymers
Funding
- Basic Science Research Program [2016R1A2B4011184]
- National Research Foundation of Korea (NRF) - Korean government, MSIP [NRF-2017M3A9E2056374]
- National Research Foundation of Korea - Ministry of Science, ICT & Future Planning [2014M3C1A3053035]
- Chonnam National University Hwasun Hospital Institute for Biomedical Science [HCRI 17901-22]
- CNUH-GIST [CRI16071-3]
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To date, numerous delivery systems based on either organic or inorganic material have been developed to achieve efficient and sustained delivery of therapeutics. Hydrogels, which are three dimensional networks of crosslinked hydrophilic polymers, have a significant role in solving the clinical and pharmacological limitations of present systems because of their biocompatibility, ease of preparation and unique physical properties such as a tunable porous nature and affinity for biological fluids. Development of an in situ forming injectable hydrogel system has allowed excellent spatial and temporal control, unlike systemically administered therapeutics. Injectable hydrogel systems can offset difficulties with conventional hydrogel-based drug delivery systems in the clinic by forming a drug/gene delivery or cell-growing depot in the body with a single injection, thereby enabling patient compliance and comfort. Carbohydrate polymers are widely used for the synthesis of injectable in situ-forming hydrogels because of ready availability, presence of modifiable functional groups, biocompatibility and other physiochemical properties. In this review, we discuss different aspects of injectable hydrogels, such as bulk hydrogels/macrogels, microgels, and nanogels derived from natural polymers, and their importance in the delivery of therapeutics such as genes, drugs, cells or other biomolecules and how these revolutionary systems can complement existing therapeutic delivery systems. (C) 2017 Elsevier B.V. All rights reserved.
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