Journal
GENE
Volume 562, Issue 2, Pages 188-196Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2015.02.070
Keywords
Sheep; Gene expression regulation; mRNA; miRNA
Categories
Funding
- Major Science and Technology Project of New Variety Breeding of Genetically Modified Organisms [2009ZX08008-004B, 2008ZX08008-003]
- National High Technology Research Development Program of China (863 Program) [2008AA10Z140]
- National Natural Science Foundation of China [30571339]
- Agricultural Science and Technology Innovation Program [ASTIP-IAS05]
- Innovation Research Foundation of CAAS [2004-CAAS-1]
- Basic Research Fund for Central Public Research Institutes of CAAS [2013ywf-yb-5, 2013ywf-zd-2]
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Sheep are highly diverse species raised for meat and other agricultural products. The aim of the present study was to investigate the genetic regulators that could control muscle growth and development in different sheep breeds. The study showed that the differentially expressed genes are involved in various cellular activities, such as metabolic cascades, catalytic function and signaling pathway. Many signaling molecules are also found to be differentially expressed, suggesting important roles of signaling pathways contributing to genetic diversity and sheep development. Analysis of miRNAs suggested important roles of miRNAs in controlling muscle differences. This study provided a genome-wide resolution of mRNA and miRNA regulations in muscles from Dorset and Han sheep. (C) 2015 Elsevier B.V. All rights reserved.
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