4.7 Article

Gelatin stabilization of quantum dots for improved stability and biocompatibility

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 107, Issue -, Pages 635-641

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.09.039

Keywords

Quantum dots; Gelatin; Cytotoxicity

Funding

  1. Department of Biotechnology (DBT-Nanomedicine), Government of India [BT/PR10085/NNT/28/99/2007]

Ask authors/readers for more resources

We herein report an aqueous synthesis of gelatin stabilized CdTe/CdS/ZnS (CSSG) core/double shell quantum dots (QDs) with improved biocompatibility. The as-synthesized QDs were characterized by ultraviolet-visible (UV-vis) and photoluminescence (PL) spectroscopic techniques, x-ray diffraction technique (XRD), x-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The CSSG QDs revealed high photoluminescence quantum yield (PLQY) with excellent stability over a period of one year and retained 90% of its initial PLQY without any aggregation or precipitation under ambient condition. The cell viability study conducted on HeLa, cervical cancer cell lines indicated that the gelatin stabilization effectively decreased the QDs cytotoxicity by about 50%. The CSSG QDs were conjugated with transferrin (Tf) for the efficient delivery to the cancer cells followed by fluorescence imaging. The results showed that the CSSG QDs illuminates the entire cell which renders the QDs as cell labeling markers. The gelatin stabilized core/double shell QDs are potential candidates for long time fluorescent bio-imaging. (C) 2017 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available