Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 111, Issue -, Pages 498-504Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.01.063
Keywords
Banana starch; Nanoparticles; Curcumin; Acetylated starch
Funding
- Vicerrectoria de Investigaciones
- Facultad de Ciencias Basicas y Tecnologias
- Facultad de Ciencias Agropecuarias
- Programa de Quimica
- Programa de Ingenieria de Alimentos
- FEDEPLATANO
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In recent years, starch nanoparticles have been of great interest for drug delivery due to their relatively easy synthesis, biocompatibility, and vast amount of botanical sources. Native and acetylated starch obtained from green bananas were used for synthesis of curcumin-loaded starch nanoparticles. Mean particle size, encapsulation efficiency, and curcumin release in simulated gastric and intestinal fluids were studied. Both nanosystems showed sizes lower than 250 nm and encapsulation efficiency above 80%, with acetylated banana starch nanoparticles having the capacity to encapsulate more curcumin molecules. Both FTIR and XRD analyses showed that starch acetylation allows stronger hydrogen bond interaction between curcumin and the starch matrix, thus, higher encapsulation efficiency. Finally, curcumin release studies showed that acetylated banana starch nanoparticles allowed more controlled release, probably due to their stronger hydrogen bond interaction with curcumin. (C) 2018 Published by Elsevier B.V.
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