Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 111, Issue -, Pages 237-246Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.01.021
Keywords
Silk fibroin; Graphene oxide; Strength; Biocompatibility; Phase separation
Funding
- High Education Science Foundation of Jiangsu Province [16KJB540005]
- Open Project Program of Key Laboratory of Eco-textiles, Ministry of Education, Jiangnan University [KLET1601]
- Open Project Program of Key Laboratory of New Textiles and Application, Hubei Province, Wuhan Textile University [Fzxc12017016]
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions [PPZY2015C254]
- Agricultural Support Program of Yancheng, Jiangsu Province [2016012, 2015028]
- Scientific Research Fund of Yancheng Institute of Industry Technology [ygy1505, ygy1409]
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Silk fibroin (SF) is blended with graphene oxide (GO) to prepare the strong and biocompatible three dimensional porous SF/GO blended scaffold via phase separation. GO could be well dispersed in SF solution and GO could also be well distributed in the SF scaffold. Furthermore, the introduction of GO can lead to structural change in the bended scaffold. Higher concentration of GO resulted in more compact structure and smaller pore size of the composite scaffolds without decreasing their porosity. Scanning electron microscopy and energy dispersive spectrometry results also reveal that SF and GO are homogeneous blended together. Analysis of chemical structures of the scaffold shows that addition of GO do not affect the crystalline structure of SF and it is evenly blended with SF. The blended scaffold has significantly higher breaking strength than the pure SF scaffold. In vitro study indicates that both pure SF scaffold and SF/GO composite scaffold support growth and proliferation of MC3T3-E1 osteoprogenitor cells. However, the addition of GO contribute to the proliferation of MC3T3-E1 osteoprogenitor. The testing results show that the blended scaffold is an appropriate candidate for tissue engineering. (C) 2018 Elsevier B.V. All rights reserved.
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