Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 112, Issue -, Pages 1191-1198Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.01.217
Keywords
Chitosan; Marine peptides; Burns healing
Funding
- Project of Science and Technology Plan of Guangdong Province [2015A020216019, 2017A010103023]
- Guangdong Provincial Natural Science Foundation of China [2016A030308009]
- Project of Enhancing School With Innovation of Guangdong Ocean University [GDOU2013050221, GDOU2016050255]
- Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences [1630122017009]
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The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing. (C) 2018 Elsevier B.V. All rights reserved.
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