Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 111, Issue -, Pages 311-318Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.01.005
Keywords
Ulmus pumila L; Pectic polysaccharide; Structural analysis; Selenylation; Anti-inflammatory properties
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2015R1D1A1A01059564]
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The specific objective of this study was to investigate characterization, selenylation, and anti-inflammatory activities of pectic polysaccharides extracted from Ulmus pumila L (PPU). Four different monosaccharides were found in PPU, including galacturonic acid, galactose, rhamnose, and glucose. FT-IR spectra indicated that pectic polysaccharides were successfully extracted from Ulmus pumila L, and were probably low methoxyl pectin. GC-MS and NMR analysis of PPU suggested the major monosaccharide of PPU was alpha-1,4-linked galacturonic acid with alpha-1,2-linked rhamnose as the backbone and glucose or galactose residues as branches at C-3 and C-4 positions of rhamnose. Selenylation of PPU was synthesized by 0.2 and 0.4% of sodium selenites. Selenized-PPU (Se-PPU) inhibited LPS-induced nitric oxide production in RAW 264.7 cells, and increasing selenium content enhanced anti-inflammatory properties of PPU. Therefore, Se-PPU can be used as a potential source of bioactive compounds for nutraceuticals and pharmaceutical applications. (C) 2018 Elsevier B.V. All rights reserved.
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