Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 112, Issue -, Pages 1248-1256Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.02.029
Keywords
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Funding
- Diretoria de Relacoes Internacionais (DRI) - Programas Estrategicos from the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil) [99999.007699/2015-08, 43/2013]
- Fundacao para a Ciencia e Tecnologia (FCT) [UID/MAR/04292/2013]
- Laboratorio de Carboidratos e Lectinas (CARBOLEC, Brazil)
- Laboratorio de Polimeros e Inovacao de Materiais (LPIM, Brazil)
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This study assessed the antioxidant, antimicrobial, anticancer and neuroprotective activities of the kappa(k)-car-rageenan isolated from the red alga Hypnea musciformis (Hm-SP). The chemical spectrum of the k-carrageenan from Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y) cell-lines, However, it was observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects or changes in the cell proliferation on Balb/c 3T3 mouse fibroblast cell-line. In summary, our data suggest that Hm-SP shows antimicrobial, anticancer and neuprotective activities. (C) 2018 Elsevier B.V. All rights reserved.
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