Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 117, Issue -, Pages 407-417Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.03.127
Keywords
FTIR; XRD; GC-MS; Diabetes; Liver-kidney functions
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The aim of this work was to evaluate the chemical characterization of a sulfated polysaccharide isolated from Codium fragile alga (CFSP), using various assays such as FTIR, XRD, GC-MS and NMR spectroscopy including H-1, C-13, COSY, HSQC, HMBC and NOESY experiments as well as its inhibitory effects on alpha-amylase activity, liver kidney toxicities and lipid profile disorders in alloxan-induced diabetic rats. Combined results showed that the CFSP is composed mainly by a galactopyranose and D-glucose, with these various bonds and these various functional groups. The antihyperglycaemic effect of this polysaccharide resulted in a significant decrease in blood glucose and intestinal amylase levels. It had the effect of significantly restoring the hepatic, pancreatic and renal antioxidant enzymes with a significant reduction in TBARS levels. The CFSP also acted at the tissue by moderating the appearance of lipid vacuoles at the hepatocytes and restoring the general histological organization of the kidneys and pancreas. (C) 2018 Published by Elsevier B.V.
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