Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 109, Issue -, Pages 1006-1011Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.11.085
Keywords
Twin-tailed surfactant; Biomacromolecule (HEWL); Modeling; Fluorescence
Funding
- UGC [F.7-222/2009(BSR)]
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Herein, we have examined the interaction of oxy-diester novel twin tailed (gemini) surfactant, 2,2'-[(oxybis(ethane-1,2-diyl))bis(oxy)bis(N-hexadecyl-N,Ndimethyl-2-oxoethanaminium) dichloride (C-16-E2O-C-16) with hen egg white lysozyme (HEWL), utilizing a spectroscopic and molecular docking spectroscopic results validated the conformational, structural and micro-environmental changes in HEWL upon interaction with C-16-E2O-C-16. Molecular modeling has shown that C-16-E2O-C-16 binds in the proximity of hydrophobic moieties (Trp-62/108). We believe the results of the current study will assist in designing the surfactant-enzyme systems for their end use as ingredients in pharmaceutical, cosmetic, drug delivery and industrial compilations. In terms of scientific literature standpoint, it will also enrich and widen the scope of biomacromolecule-surfactant interactions. (C) 2017 Elsevier B.V. All rights reserved.
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