Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 106, Issue -, Pages 418-424Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.08.038
Keywords
Hydrophobic modification sodium alginate with different molecular weight; Self-aggregation; Nano-delivery vehicle
Funding
- National Natural Science Foundation of China [21366010, 21566009]
- Natural Science Foundation of Hainan Province [213010, 20162013, 20162016]
- Key Projects in the Hainan provincial Science & Technology Program [cxy20150026]
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In this study, cholesteryl-grafted sodium alginate derivatives (CSAD) with different molecular weights were synthesized by esterification. The structure of CSAD was confirmed by FT-IR and H-1 NMR spectrometers. The effects of pH and CSAD polymer concentration on the self-assembled behavior and particle size of CSAD were investigated by fluorescence measurement (FM) and dynamic light scattering (DLS). In the presence of Cat(2+), the cholesteryl-grafted sodium alginate derivative was used for fabricating self-assembled nanoparticles that can effectively encapsulate the drug acetamiprid. The drug-loaded nanoparticles were characterized by transmission electron microscopy (TEM). The encapsulation efficiency (EE) and acetamiprid drug release behavior from the nanoparticles were also studied. The results reveal that CSAD self-assembled nanoparticles had a diameter of 100 nm and were nonaggregated in aqueous media; Moreover, the encapsulation efficiency and the release behavior of nanoparticles were influenced by the MW of CSAD. The mechanism of acetamiprid release was found to vary from non-Fickian (anomalous) to Fickian transport with a decrease in the molecular weight of CSAD. (C) 2017 Elsevier B.V. All rights reserved.
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