Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 106, Issue -, Pages 185-192Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.08.008
Keywords
Anti-inflammatory effects; Antioxidative effects; Enzymatic- and acidic-polysaccharides; Lentinula edodes residue; Lung injury
Funding
- Mushroom Technology System of Shandong Province [SDAIT-07-05]
- Fundamental Research Funds for Central Non-profit Scientific Institution [1610132016041]
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In present study, two hydrolyzed residue polysaccharides (RPS) of enzymatic-RPS (ERPS) and acidic-RPS (ARPS) were successfully obtained from the residue of Lentinula edodes, and the anti-inflammatory as well as antioxidative effects on lipopolysaccharide-induced (LPS-induced) lung injured mice were investigated. The results demonstrated that ERPS showed superior lung protective effects by ameliorating the lung wet-to-dry weight (W/D) ratio, reducing the TNF-alpha, IL-6, and IL-1 beta levels in BALF, lowing the pulmonary MPO activity, decreasing the serum C3 and hs-CPR contents, as well as improving the antioxidant status by enhancing pulmonary enzyme activities (SOD, GSH-Px, CAT, and T-AOC) and eliminating the lipid peroxidation (MDA and LPO), respectively. These conclusions indicated that both RPS and its hydrolysates (ARPS and ERPS) might be suitable for functional foods and a potentially effective candidate medicine for the treatment of lung injury. (C) 2017 Elsevier B.V. All rights reserved.
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