Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 106, Issue -, Pages 1166-1172Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.08.115
Keywords
Electro-spun silk web; Molecular weight; Mechanical properties
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF- 2017R1A2B4003655]
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Owing to the excellent biocompatibility of silk fibroins (SFs) and ease of fabrication of nano-fibrous webs by the electro-spinning technique, electro-spun SF webs have attracted the attention of researchers for various biomedical applications, including their use as tissue engineering scaffolds and membranes for guided bone regeneration. In this work, the effect of the molecular weight (MW) and concentration of SFs on the structure and properties of the electro-spun SF webs was examined. The fiber morphology and porosity of these SF webs were strongly affected by the viscosity of the SF dope solution. It was found that the electro-spinning rate of the SF solution could be increased significantly (7.5 fold) by controlling the MW and concentration of the SF. Interestingly, as the SF MW and concentration (i.e., solution viscosity) increased, the extent of beta-sheet crystallization of the SF decreased, leading to a decrease in the overall crystallinity. The strength and elongation of the electro-spun SF web decreased with an increase in the web porosity (i.e., increasing SF concentration) and a decrease in the MW of the SF. (C) 2017 Elsevier B.V. All rights reserved.
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