Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 114, Issue -, Pages 381-391Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.03.106
Keywords
Hydrogel; Chitosan; Hydroxypropyl beta-cyclodextrin; Diels-Alder reaction; Drug delivery
Funding
- National Natural Science Foundation of China [31230057, 31401524]
- Natural Science Foundation of Jiangsu Province [BK20140143]
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Chitosan-cyclodextrin hydrogel (CFCD) was prepared via Diels-Alder reaction between furfural functionalized chitosan (CF) and N-maleoyl alanine functionalized hydroxypropyl beta-cyclodextrin (HPCD-AMI) in aqueous media without any catalyst or initiator. The CF and HPCD-AMI were confirmed by Fourier transform infrared spectroscopy and H-1 nuclear magnetic resonance spectroscopy. The resultant CFCD hydrogel was characterized in terms of thermal peripteries, microstructure, rheology behavior, and swelling capacity. The rheology analysis found that the storage modulus G' ranged from 1 pa to 1200 pa as the degree of furfural substitute on chitosan increased from 2.6% to 283%, indicating the hydrogel strength can be tuned readily by reaction stoichiometry. The swelling behaviors proved that CFCD hydrogel was pH-responsive with low swelling capacity, which would be preferable for drug delivery. Drug adsorption analysis showed the introduction of cyclodextrin into CFCD hydrogels promoted drug adsorption capacity. In addition, methyl orange cumulative release in PBS buffer was only 48.85% after 24 h, suggesting CFCD hydrogel had good sustained release capacity on the loaded drug. (C) 2018 Elsevier B.V. All rights reserved.
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