Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 98, Issue -, Pages 75-81Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2018.03.006
Keywords
Hippo; TGF-beta; Cell density; Cell polarity; Signal transduction
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Funding
- Ligue Nationale Contre le Cancer (Equipe Labellisee LIGUE)
- Institut National du Cancer [INCa MELA13-002]
- INSERM
- CNRS
- Institut Curie
- Donation Henriette et Emile Goutiere
- Universite Paris-Sud
- Ministry of Higher Education, Research and Innovation (France)
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The ubiquitous distribution of both Hippo and TGF-beta signaling cascade components and their critical implication in tissue homeostasis and disease has led to the discovery of a remarkable slew of interesting and unique features regarding their functional crosstalks. Upstream cellular cues regulating the Hippo pathway, including cell cell contacts and apico-basal cell polarity have been well characterized. Herein, we provide an overview of the published models of compartmentalized signaling crosstalk mechanisms between Hippo signaling and the TGF-g/SMAD pathway. How cell polarity impacts the interaction between the two pathways is discussed, together with the specifics of cytoplasmic and nuclear events implicating SMADs and YAP/TAZ, leading to contextual regulation of target gene expression.
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