Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 51, Issue 1, Pages 145-150Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2017.09.008
Keywords
Pseudomonas aeruginosa; Multidrug resistance; Megaplasmid; qnrVC6; aacA4-bla(IMP-45)-bla(OXA-1)-catB3
Funding
- National Key Research and Development Program of China [2016YFD04012021]
- Guangdong Special Support Program [2016TQ03N682]
- National Natural Science Foundation of China [81201341]
- Pearl River S&T Nova Program of Guangzhou [201710010061]
- Science and Technology Planning Project of Guangdong Province [2017A050501007]
- National Outstanding Doctoral Dissertation Funding [201459]
- Fundamental Research Funds for the Central Universities [2017ZD092]
- Open Research Fund of State Key Laboratory of Biological Fermentation Engineering of Beer [K2017001]
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This study aimed to characterise a novel multidrug resistance megaplasmid carrying qnrVC6 and bla(IMP-45) from Pseudomonas aeruginosa strain Guangzhou-Pae617 isolated from a patient hospitalised in Guangzhou, China, in 2012. The plasmid pBM413 has a length of 423 017 bp and an average G + C content of 56.41%. A qnrVC6 gene flanked by two copies of insertion sequence (IS) elements ISCR1, a multiresistance class 1 integron In786 containing aacA4-bla(IMP-45)-bla(OXA-1)-catB3 cassettes, an armA gene, and an aphA7 gene flanked by two copies of IS26 were identified. To our knowledge, this is the first identification of a qnrVC6 gene in P. aeruginosa. (c) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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