Journal
ABDOMINAL IMAGING
Volume 40, Issue 8, Pages 3248-3256Publisher
SPRINGER
DOI: 10.1007/s00261-015-0500-2
Keywords
Renal cell carcinoma; Microwave ablation; Laparoscopy; Nephrectomy; Survival
Funding
- National Scientific Foundation Committee of China [81430039, 81127006, 81401436]
- Beijing Natural Science Foundation [7144246]
- State Key Laboratory of Kidney Diseases
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Laparoscopic radial nephrectomy (LRN) and microwave ablation (MWA) are optional treatment for renal cell carcinoma (RCC). However, the comparative study with two techniques remains lacking. The aim of this study was to evaluate midterm results of MWA vs. LRN in patients with small RCC. A total of 426 patients with a parts per thousand currency sign4 cm RCC were included from April 2006 to October 2012. Ninety-eight patients underwent MWA and 328 patients LRN. The survival, recurrence, and renal function changes were compared between two treatments. Although overall survival after MWA (82.6% at 5 years) was lower than those after LRN (98.6% at 5 years, p = 0.0004), the RCC-related survival (97% at 5 years) was comparable to those following LRN (98% at 5 years, p = 0.38). One local tumor progress occurred at 32 months after MWA and none after LRN. The major complication rates were comparable between two techniques (1.7% in MWA vs. 1.5% in LRN, p = 0.75), but MWA showed less renal function damage than LRN (p < 0.0001). The multivariate analysis showed the presence of postablation extrarenal metastasis may become a predictor of the oncologic outcome (p = 0.059) and treatment modality had no influence (p = 0.965). This study demonstrates that MWA and LRN provide comparable results in small RCC outcomes.
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