Journal
CHINESE JOURNAL OF NATURAL MEDICINES
Volume 12, Issue 12, Pages 937-942Publisher
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(14)60137-0
Keywords
Emodin; Cytotoxicity; Metal complex; Cell cycle arrest; Apoptosis
Funding
- Natural Science Foundation Project of CQ CSTC [2011BB5109]
- Program for Innovation Team Building at Institutions of Higher Education in Chongqing [KJTD201325]
- Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education [CQKLBST-2012-007]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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To synthesize and characterize a novel metal complex of Mn (II) with emodin, and evaluate its anti-cancer activity. The elemental analyses, IR, UV-vis, atomic absorption spectroscopy, TG-DSC, (HNNIR)-H-1, and C-13 NMR data were used to characterize the structure of the complex. The cytotoxicity of the complex against the human cancer cell lines HepG2, HeLa, MCF-7, B16, and MDA-MB-231 was tested by the MTT assay and flow cytometry. Emodin was coordinated with Mn(II) through the 9-C=O and 1-OH, and the general formula of the complex was Mn(II) (emodin)(2)center dot 2H(2)O. In studies of the cytotoxicity, the complex exhibited significant activity, and the IC50 values of the complex against five cancer cell lines improved approximately three-fold compared with those of emodin. The complex could induce cell morphological changes, decrease the percentage of viability, and induce G(0)/G(1) phase arrest and apoptosis in cancer cells. The coordination of emodin with Mn(II) can improve its anticancer activity, and the complex Mn(II) (emodin)(2)center dot 2H(2)O could be studied further as a promising anticancer drug.
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