Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 61, Issue -, Pages 119-125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2018.05.023
Keywords
IL-34; Inflammation; Fibroblasts
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Funding
- National Natural Science Foundation of China [81300006]
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IL-34 plays diverse roles in disease due to its inflammatory and immunosuppressive properties. Elevated IL-34 expression has been observed in lung cancers and pulmonary infections although its role is unclear. We found that IL-34 addition to primary lung fibroblasts significantly promoted IL-6 and IL-8 expression in a dose and time dependent manner. These effects were reversed when JAK, NF-kappa B Akt and p38 inhibitors were included before IL-34 addition. Protein phosphorylation in these pathways was also observed through western-blotting. Stimulation of human lung fibroblasts with IL-34 in combination with TNF-alpha, IL-17A and IL-4 enhanced inflammatory cytokine production. Our data confirmed the inflammatory effect of IL-34 on human lung fibroblasts and suggested that the IL-34/CSF-1R axis may be a novel therapeutic target in pulmonary disease.
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