Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 55, Issue -, Pages 38-48Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2017.12.001
Keywords
Methionine enkephalin; Influenza A virus; Toll-like receptors; Opioid receptors; Antiviral efficacy
Categories
Funding
- National Natural Science Foundation of China [31670921]
- China Liaoning Province Supporting Construction of Discipline Platforms in Universities
Ask authors/readers for more resources
The morbidity and mortality associated with influenza A virus infections, have stimulated the search for novel prophylactic and therapeutic drugs. The purpose of this study was to investigate the prophylactic and therapeutic effect of synthetic methionine enkephalin (MENK) on mice infected by A/PR/8/34 influenza virus (H1N1) in vivo. The results showed that MENK could exert both prophylactic and therapeutic influences on infected mice, significantly improve the survival rate, relieve acute lung injury and decrease cytokine (IFN-alpha, IFN-beta, TNF-alpha, IL-6, and IL-1 beta) levels. MENK also inhibited virus replication on day 4 post infection (p.i.) through upregulating opioid receptors (MOR, DOR) and suppressing TLR7-MyD88-TRAF6-NF-kappa B p65 signaling pathways. These results suggest that MENK, given via intranasal administration, could provide a novel drug with a new mode of action as a nonspecific anti-influenza agent or vaccine adjuvant.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available