Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 55, Issue -, Pages 1-8Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2017.11.043
Keywords
Telbivudine; Chronic kidney disease; Renal fibrosis; Inflammation
Categories
Ask authors/readers for more resources
Renal fibrosis yields decreased renal function and is a potent contributor to chronic kidney disease (CKD). Telbivudine (LdT) is an anti-hepatitis B virus (HBV) drug that has been found to steadily improve renal function, but the mechanism of drug action is unclear. One explanation is that LdT impacts inflammatory or fibrotic pathways. In this study, we investigated renal protection by LdT in a rat model of unilateral ureteral obstruction (UUO). UUO rats received oral gavage of LdT (1, 1.5, or 2 g/kg/day) for 5 weeks. Kidney tissues were examined histopathologically with hematoxylin and eosin and Masson's trichrome stain. To assess proliferation of myofibroblasts and matrix accumulation, a-smooth muscle actin (alpha-sma) and collagen type I and III were detected. Interleukin-1 (IL-1) and tumor necrosis factor (TNF)-alpha were evaluated as a measure of proinfiammatory cytokines. Transforming growth factor (TGF)-beta and nuclear factor-kappa B (NF-kappa B) were considered the canonical signaling components in our investigation of the underlying mechanism of LdT action. Histopathology results indicated that LdT ameliorates renal injury and matrix accumulation. Expression of a-sma and collagen I/III as well as key fibrotic signaling factors in the TGF-beta/Smad pathway were downregulated. In addition, LdT suppressed the release of IL-1 and TNF-alpha and decreased the expression of NF-kappa B by inhibiting toll-like receptor 4. Taken together, these findings indicate that LdT can attenuate renal fibrosis and inflammation via TGF-beta/Smad and NF-kappa B pathways in UUO.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available