Journal
INTERNAL MEDICINE
Volume 57, Issue 10, Pages 1463-1468Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.0139-17
Keywords
cerebral toxoplasmosis; rheumatoid arthritis; nested-PCR; methotrexate
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A 65-year-old woman with rheumatoid arthritis (RA) visited our hospital because of right facial sensory hypoesthesia. Cerebral toxoplasmosis was suspected on brain magnetic resonance imaging. We discontinued methotrexate for RA and started a sulfamethoxazole/trimethoprim (ST) mixture. Although ST treatment was interrupted because of adverse reactions, her prognosis was favorable. The Toxoplasma 18S rDNA gene was detected by nested-polymerase chain reaction (PCR) from blood and cerebrospinal fluid. Detecting the Toxoplasma 18S rDNA gene by nested-PCR is useful for the diagnosis and safer than a brain biopsy. In addition, the discontinuation of immunosuppressants may be recommended in patients compromised by those immunosuppressants.
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