Journal
INTEGRATIVE CANCER THERAPIES
Volume 17, Issue 3, Pages 674-683Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1534735418762537
Keywords
Ganoderma lucidum polysaccharides; glioma; antitumor; immunomodulation; tumor-bearing rat model
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Funding
- China National Engineering Research Center of Juncao Technology [JCJJ14008]
- Medical Innovation Project of Fujian Province [2016-CX-18]
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Malignant gliomas are the most common brain tumors with high rates of recurrence and mortality. Novel approaches are in research, and immunotherapy emerges as a promising strategy. Recently, scientific attention has been focused on Ganoderma lucidum polysaccharides (GL-PS), one of the critical bioactive components of G lucidum, which have been recognized as a promising natural source of immunomodulatory and anticancer compounds. It remains unknown whether the GL-PS have any immunomodulatory and anticancer effects on brain glioma. This study was designed to identify and characterize the antitumor action and influence of immune system of GL-PS in glioma-bearing rats. Results showed that GL-PS increased the concentration of serum interleukin-2, tumor necrosis factor-alpha, and interferon-gamma, and enhanced the cytotoxic activity of natural killer cells and T cells, promoting the functional maturation of dendritic cells, thus resulting in the inhibition of glioma growth and prolonged survival of rats. Therefore, GL-PS may be potentially useful as part of the treatment regimen to regulate host immune responses and increase the antitumor effects of immunotherapy for glioma.
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